Specifications
- Antibody Type:Primary
- Antigen Name:Neutrophil Elastase
- Antigen Symbol:NE
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Human
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:1991
- Antigen Synonyms:Human Leukocyte Elastase|PMN-E|Bone Marrow Serine Protease|HLE|HNE|PMN Elastase|Medullasin|Polymorphonuclear Leukocyte Elastase|Neutrophil Elastase|ELA2|ELANE
- Amino Acid Number:30 - 247
- UniProtKB:P08246
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:53/28 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant NE(Ile30~Gln247)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAA181HU1
- Packaging:Vial
Specifications
About this item
Polyclonal antibody to Neutrophil Elastase (NE), derived from recombinant NE(Ile30~Gln247), is reactive with Human.
- High specificity, affinity and purity
- Extensive validation and batch-to-batch consistency
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Neutrophil elastase is a serine protease in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils during inflammation, it destroys bacteria and host tissue. As with other serine proteases it contains a charge relay system composed of the catalytic triad of histidine, aspartate, and serine residues that are dispersed throughout the primary sequence of the polypeptide but that are brought together in the three dimension conformation of the folded protein. The gene encoding neutrophil elastase, ELA2, consists of five exons. The neutrophil form of elastase is 218 amino acids long, with two asparagine-linked carbohydrate chains. It is present in azurophil granules in the neutrophil cytoplasm. There appear to be two forms of neutrophil elastase, termed IIa and IIb.
Type: Primary
Antigen: NE
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human