- Antibody Type:Primary
- Antigen Name:Complement Component 8b
- Antigen Symbol:C8b
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:110382
- Antigen Synonyms:Complement component 8 subunit beta
- Amino Acid Number:161 - 503
- UniProtKB:Q8BH35
- Storage Buffer:PBS, pH 7.4, containing 0.02% NaN₃, 50% glycerol
- Molecular Weight:43 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant C8b(Cys161~Arg503)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAB306MU1
- Packaging:Vial
Polyclonal antibody to Complement Component 8b (C8b), derived from recombinant C8b(Cys161~Arg503), is reactive with Mouse.
- High specificity, affinity and purity
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Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.Patients with deficiency of C8 suffer from recurrent neisserial infections, predominantly with meningococcus infection of rare serotypes. Most such patients are discovered among those having their first episode of meningitis at ages older than 10 years. C8 deficiency of the alpha and gamma subunits was found in 4 black families and no Caucasian families by Ross and Densen (1984), whereas C8B deficiency was reported in 12 Caucasian kindreds and no black kindreds. Wulffraat et al. (1994) described a family in which a 13-year-old boy was found to be homozygous for C8B deficiency and to have juvenile chronic arthritis of 6 months' duration.Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected.
Type: Primary
Antigen: C8b
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse