- Antibody Type:Primary
- Antigen Name:Matrix Metalloproteinase 12
- Antigen Symbol:MMP12
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Rat,Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:17381
- Antigen Synonyms:Macrophage Metalloelastase|Macrophage Elastase|MME|ME|HME
- Amino Acid Number:294 - 473
- UniProtKB:P34960
- Storage Buffer:PBS, pH 7.4, containing 0.02% NaN₃, 50% glycerol
- Molecular Weight:23 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant MMP12(Ala294~Cys473)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAA402MU1
- Packaging:Vial
Polyclonal antibody to Matrix Metalloproteinase 12 (MMP12), derived from recombinant MMP12(Ala294~Cys473), is reactive with Mouse/Rat.
- High specificity, affinity and purity
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Matrix metallopeptidase 12 is part of a cluster of MMP genes which localize to chromosome 11q22.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema.
Type: Primary
Antigen: MMP12
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat