Specifications
- Antibody Type:Primary
- Antigen Name:Immunoglobulin G1
- Antigen Symbol:IgG1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Human
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Antigen Synonyms:IGHG1|Ig Gamma-1 Chain C Region|Immunoglobulin Heavy Constant Gamma 1|Immunoglobulin Gm1|G1m Marker
- Amino Acid Number:full-length
- UniProtKB:P01768
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:55/25 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:native IgG1
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAA074HU1
- Packaging:Vial
Specifications
About this item
Polyclonal antibody to Immunoglobulin G1 (IgG1), derived from native IgG1, is reactive with Human.
- High specificity, affinity and purity
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IgG is the predominant immunoglobulin in the serum and has a molecular weight of about 150 kDa. Four distinct subgroups of human IgG (IgG1, IgG2, IgG3, and IgG4) were first demonstrated in the 1960’s by using polyclonal antisera prepared in animals immunized with human myeloma proteins. Quantitatively, the relative serum concentrations of the IgG subclasses are as follows: IgG1 > IgG2 > IgG3 = IgG4. The four IgG subclasses show their most conspicuous differences in the amino acid composition and structure of the 'hinge region', which is the part of the molecule containing disulfide bonds between the y-heavy chains. The hinge region of IgG1 encompasses amino acids 216 to 231 and since it is freely flexible, the Fab fragments can rotate about their axes of symmetry and move within a sphere centered at the first of two inter-heavy chain disulfide bridges.
Type: Primary
Antigen: IgG1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human