Specifications
- Antibody Type:Primary
- Antigen Name:Nesprin 2
- Antigen Symbol:Nesp2
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Pig,Human
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Antigen Synonyms:NUANCE|Nucleus and actin connecting element protein|Nuclear envelope spectrin repeat protein 2|SYNE-2|Synaptic nuclear envelope protein 2|SYNE2|NUA
- Amino Acid Number:6 - 296
- UniProtKB:Q8WXH0
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:37 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant Nesp2(Glu6~Gln296)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAF952HU1
- Packaging:Vial
Specifications
About this item
Polyclonal antibody to Nesprin 2 (Nesp2), derived from recombinant Nesp2(Glu6~Gln296), is reactive with Human/Pig.
- High specificity, affinity and purity
- Extensive validation and batch-to-batch consistency
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SYNE2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. SYNE2 contains multiple spectrin repeats and a 60-amino acid C-terminal region homologous to the Drosophila protein Klarsicht. RT-PCR analysis showed low to moderate expression of 2 SYNE2 splice variants in most tissues examined, including skeletal and cardiac muscle, kidney, liver, pancreas, and placenta, and indicated that alternative splicing patterns are conserved between SYNE1 and SYNE2.Nesprin-2-gamma also has a bipartite nuclear localization signal and a leucine zipper motif.
Type: Primary
Antigen: Nesp2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Pig