- Antibody Type:Primary
- Antigen Name:Complement Factor H
- Antigen Symbol:CFH
- Clonality:Monoclonal
- Clone:C3
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG2b kappa
- Reactivity:Rat
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:155012
- Antigen Synonyms:HUS|ARMS1|HF2|FH|Adrenomedullin binding protein|CFHL3|CF-H|HF1|FHL1|Age-Related Maculopathy Susceptibility 1|ARMD4|H Factor 2
- Amino Acid Number:975 - 1217
- UniProtKB:G3V9R2
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Storage Temperature:Store at 2...8 °C for frequent use,−20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:1 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:recombinant CFH (Ala975~Ser1217)
- Purification:Protein A + Protein G affinity chromatography
- Cat. No.:MSPP-MAA635RA2
- Packaging:Vial
Monoclonal Antibody to Complement Factor H (CFH), derived from recombinant CFH (Ala975~Ser1217), is reactive with Rat.
- High specificity, affinity and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
- All in stock and fast global delivery
- 100% Quality and service satisfaction guarantee
Factor H is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at a concentration of 500 to 800 micrograms per milliliter). Its main job is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens and does not damage host tissue. Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. Factor H protects self cells from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.
Type: Primary
Antigen: CFH
Clonality: Monoclonal
Clone: C3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b Kappa
Reactivity: Rat