Specifications
- Antibody Type:Primary
- Antigen Name:Wingless Type MMTV Integration Site Family, Member 5A
- Antigen Symbol:WNT5A
- Clonality:Monoclonal
- Clone:C3
- Conjugation:Unconjugated
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:22418
- Amino Acid Number:62 - 380
- UniProtKB:p22725
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:40 kDa
- Storage Temperature:Store at 2...8 °C for frequent use,−20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:1 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:recombinant WNT5A (Ile62~Lys380)
- Purification:Protein A + Protein G affinity chromatography
- Cat. No.:MSPP-MP549MU21
- Packaging:Vial
Specifications
About this item
Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A), derived from recombinant WNT5A (Ile62~Lys380), is reactive with Mouse.
- High specificity, affinity and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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WNT5A is a member of the WNT gene family. It encodes a protein which shows 98, 98 and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction. In the presence of a chemokine gradient, this Wnt-mediated receptor-actin-myosin polarity structure accumulates asymmetrically at the cell periphery, where it triggers membrane contractility and nuclear movement in the direction of membrane retraction. The process requires endosome trafficking, is associated with multivesicular bodies, and is regulated by Wnt5a through the small guanosine triphosphates Rab4 and RhoB.
Type: Primary
Antigen: WNT5A
Clonality: Monoclonal
Clone: C3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Mouse