Specifications
- Antibody Type:Primary
- Antigen Name:A Disintegrin And Metalloprotease 10
- Antigen Symbol:ADAM10
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:102
- Antigen Synonyms:CDw156|CD156c|Mammalian disintegrin-metalloprotease|MADM|Kuzbanian protein homolog|Kuz|CD156-C
- Amino Acid Number:420 - 641
- UniProtKB:O14672
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:30 kDa
- Storage Temperature:Store at 2...8 °C for frequent use,−20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:recombinant ADAM10 (Arg420~Val641)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAA766HU1
- Packaging:Vial
Specifications
About this item
Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10), derived from recombinant ADAM10 (Arg420~Val641), is reactive with Human/Mouse/Rat.
- High specificity, affinity and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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A Disintegrin And Metalloprotease 10 is a ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. ADAM10 is a sheddase, and has a broad specificity for peptide hydrolysis reactions. New data on the ADAM10 shedding of ephrin/eph complex associated with Eph on one cell surface has determined that ADAM10 cleaves ephrin, within the ephrin/eph complex, formed between two cell surfaces. When ephrin is freed from the opposing cell, the entire ephrin/eph complex is endocytosed. This shedding in trans had not been previously shown, but may well be involved in other shedding events.
Type: Primary
Antigen: ADAM10
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat