Anti-PKM2 Rabbit Polyclonal Antibody
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Product Details & Documents
Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2), derived from recombinant PKM2 (Lys141~Ala248), is reactive with Human.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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Pyruvate Kinase M2 (M2-PK) is strongly overexpressed in a metabolic state specific for a variety of tumor cells. Recent reports indicate that Tumor M2-PK is a marker for renal cell carcinoma and. lung cancer. It has also been investigated in. pancreatic cancer and gastric cancer with promising results., M2-PK is encoded by the gene PKM2 which does also encode for the pyruvate kinase isoenzyme type M1 (PKM1 or M1-PK). The M-gene consists of 12 exons and 11 introns. PKM1 and PKM2 are different splicing products of the M-gene (exon 9 for PKM1 and exon 10 for PKM2) and solely differ in 23 amino acids within a 56 amino acid stretch (aa 378-434) at their carboxy terminus.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please proper stored each component based on the instruction.
Type: Primary
Antigen: PKM2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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Additional Product Details
Specifications
- Size:200 µl
- Packaging:Vial
- Clonality:Polyclonal
- Molecular Weight:13 kDa
- Form:Liquid
- ImmunoFluorescence:Yes
- UniProtKB:P14618
- Antibody Type:Primary
- Gene ID:5315
- Immunogen:Recombinant PKM2 (Lys141~Ala248)
- Amino Acid Number:141 - 248
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Cross Adsorption:No
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Isotype:IgG
- Host:Rabbit
- Concentration:0.5 mg/ml (for reference only)
- Cat. No.:MSPP-PAA588HU1
- Reactivity:Human
- Western Blot:Yes
- Shipping Temperature:Shipped on blue ice at 4 °C
- Antigen Symbol:PKM2
- ImmunoChemistry:Yes
- Conjugation:Unconjugated
- Antigen Synonyms:PKM1|M2PK|THBP1|TCB|CTHBP|PKM|Pyruvate Kinase, Muscle|Thyroid hormone-binding protein 1|PK3|M2-PK|OIP3|Cytosolic thyroid hormone-binding protein|Pyruvate kinase muscle isozyme
- Antigen Name:Pyruvate kinase isozymes M2
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