Specifications
- Antibody Type:Primary
- Antigen Name:Dickkopf Related Protein 1
- Antigen Symbol:DKK1
- Clonality:Monoclonal
- Clone:C5
- Conjugation:Unconjugated
- Host:Mouse
- Isotype:IgG2b kappa
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:22943
- Antigen Synonyms:SK|Dickkopf Homolog 1(Xenopus Laevis)
- Amino Acid Number:33 - 266
- UniProtKB:O94907
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:33 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:1 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant DKK1 (Leu33~His266)
- Purification:Protein A + Protein G affinity chromatography
- Cat. No.:MSPP-MAA741HU2
- Packaging:Vial
Specifications
About this item
Monoclonal Antibody to Dickkopf Related Protein 1 (DKK1), derived from recombinant DKK1 (Leu33~His266), is reactive with Human/Mouse.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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Dickkopf-related protein 1 is a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Sequence analysis predicted that the 266-amino acid DKK1 protein contains a 31-amino acid N-terminal signal peptide, 2 clusters of cysteine residues, and a potential C-terminal N-glycosylation site. SDS-PAGE and Western blot analysis demonstrated that DKK1 is expressed as a 35-kDa doublet protein, which is larger than the deduced molecular mass of 26 kDa.
Type: Primary
Antigen: DKK1
Clonality: Monoclonal
Clone: C5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human;Mouse