Specifications
- Antibody Type:Primary
- Antigen Name:5-Lipoxygenase
- Antigen Symbol:5-LO
- Clonality:Monoclonal
- Clone:D10
- Conjugation:Unconjugated
- Host:Mouse
- Isotype:IgG2b kappa
- Reactivity:Pig,Human,Rat,Mouse
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:240
- Antigen Synonyms:LOX5|5-LOX|5LPG|ALOX-5|Lipoxygenase 5|ALOX5|LOG5
- Amino Acid Number:461 - 671
- UniProtKB:P09917
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:34 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:1 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant 5-LO(Glu461~Ser671)
- Purification:Protein A + Protein G affinity chromatography
- Cat. No.:MSPP-MB355HU21
- Packaging:Vial
Specifications
About this item
Monoclonal Antibody to 5-Lipoxygenase (5-LO), derived from recombinant 5-LO(Glu461~Ser671), is reactive with Human/Mouse/Rat/Pig.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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Arachidonate 5-lipoxygenase is a member of the lipoxygenase family. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.5-ALOX catalyzes oxidation of AA at the 5-position to yield 5-HPETE. 5-LO then converts 5-HPETE to leukotriene A4.5-ALOX is a target for pharmaceutical intervention in CAD.,Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-ALOX is expressed in brain cells and may participate in neuropathologic processes.Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
Type: Primary
Antigen: 5-LO
Clonality: Monoclonal
Clone: D10
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b Kappa
Reactivity: Human;Mouse;Rat;Pig