- Antibody Type:Primary
- Antigen Name:TNF Like Ligand 1A
- Antigen Symbol:TL1A
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human
- Western Blot:Yes
- Size:200 µl
- Cross Adsorption:No
- Form:Liquid
- Gene ID:9966
- Antigen Synonyms:VEGI192A|VEGI|TNFSF15|Vascular Endothelial Growth Inhibitor|TL1|TNF Superfamily Ligand TL1A|Tumor Necrosis Factor(ligand)Superfamily,Member 15|TNF Ligand-Related Molecule 1
- Amino Acid Number:67 - 251
- UniProtKB:O95150
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:25 kDa
- Storage Temperature:Store at 2...8 °C for frequent use, −20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:Recombinant TL1A(Val67~Leu251)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-PAC602HU1
- Packaging:Vial
Polyclonal Antibody to TNF Like Ligand 1A (TL1A), derived from recombinant TL1A(Val67~Leu251), is reactive with Human.
- High specificity, affinity, and purity
- Extensive validation and batch-to-batch consistency
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VEGI is an anti-angiogenic protein. It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. The protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
Type: Primary
Antigen: TL1A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human