The coronavirus, also known as SARS-CoV-2, enters the cell by using its surface SPIKE. SPIKE is processed on the cell's surface by TMPRSS2, a serine protease. It then subsequently binds to ACE2 a cell surface receptor.

• Alternative names: SPIKE_SARS2 Spike glycoprotein
• UniProt Number: P0DTC2
• Protein class: Single span transmembrane protein
• Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
• Sequence, explained: Full-length sequence (aa 1 – 1273), furin cleavage site 'RRAR' mutated to 'GSAG'; C-terminal Rho1D4 tag fused with spacer 'GSSG' to protein sequence
• Affinity tags: C-terminal Rho1D4-tag
• Size: 1286 amino acids (including Rho1D4-tag and linker)142114 Da
• Buffer composition: 20 mM Hepes pH 7.5; 150 mM NaCl, buffer does not contain free DIBMA Glycerol (DIBMA: Diisobutylene-maleic acid)
• Stabilization agent: DIBMA Glycerol
• Purified via: PureCube Rho1D4 Agarose
• Function: Host cell surface receptor binding; fusion of virus membrane with host endosome membrane

The Native SPIKE protein is a trimer that is located in the coronavirus membrane. Therefore to get pure and native SPIKE this trimer needs to be kept intact. And Cube Biotech offers stabilized intact form of SPIKE.