About this item
Encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 FAS1, 16 EGF-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low-density lipoprotein, gram-positive and gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008].
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both gram-positive and gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
Type: Primary
Antigen: STAB1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG (H, L)
Reactivity: Human, Mouse
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Specifications
- Catalog No:
- 77322-224
- 77322-244
- Antigen Symbol:
- STAB1
- STAB1
- Antigen Name:
- Stabilin 1
- Stabilin 1
- Antigen Synonyms:
- KIAA0246|FEEL1
- KIAA0246|FEEL1
- Antibody Type:
- Primary
- Primary
- Clonality:
- Polyclonal
- Polyclonal
- Conjugation:
- Alexa Fluor® 350
- Alexa Fluor® 350
- Reactivity:
- Human, Mouse
- Human, Mouse
- Host:
- Rabbit
- Rabbit
- Gene ID:
- Human: Q9NY15, Mouse: Q8R4Y4
- Human: Q9NY15, Mouse: Q8R4Y4
- Isotype:
- IgG (H, L)
- IgG (H, L)
- Form:
- Liquid
- Liquid
- Purification:
- Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- Storage Buffer:
- PBS containing 50% glycerol and 0.02% sodium azide
- PBS containing 50% glycerol and 0.02% sodium azide
- Storage Temperature:
- Store at −20 °C/1 year
- Store at −20 °C/1 year
- Shipping Temperature:
- Shipped on blue ice
- Shipped on blue ice