Specifications
- Antibody Type:Primary
- Antigen Name:SREBP-1/2
- Clonality:Polyclonal
- Conjugation:HRP (Horseradish Peroxidase)
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Bovine,Rat,Mouse
- Western Blot:Yes
- Size:100 µl
- Epitope:301-450/1147
- Form:Liquid
- Gene ID:6720, 6721
- Antigen Synonyms:SREBF 1|Sterol regulatory element binding protein 1|Sterol regulatory element binding transcription factor 1.|BHLHD1|SREBP 1c|ADD 1|Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1|D630008H06|SREBP1|SREBP 1|SREBF1
- Modification:Unmodified
- Storage Buffer:Aqueous buffered solution containing 0.01 M TBS (pH 7,4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- Molecular Weight:54/126 kDa
- Storage Temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze–thaw cycles.
- Concentration:1 µg/µl
- Shipping Temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human SREBP-1
- Purification:Purified by Protein A
- Cat. No.:10306-028
- Packaging:Vial
Specifications
About this item
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
Type: Primary
Antigen: SREBP-1/2
Clonality: Polyclonal
Clone:
Conjugation: HRP
Public Immunogen Range: 301-450/1147
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat; Bovine