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Specifications
- Antibody Type:Primary
- Antigen Name:GPR30
- Clonality:Polyclonal
- Conjugation:Cy5®
- Flow Cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µl
- Environmentally Preferable:
- Epitope:251-375/375
- Form:Liquid
- Gene ID:2852
- Antigen Synonyms:GPR30|G protein-coupled estrogen receptor 1|IL8-related receptor DRY12|LERGU|CEPR|GPCR-Br|Flow-induced endothelial G-protein coupled receptor 1|CMKRL2|G-protein coupled estrogen receptor 1|Chemoattractant receptor-like 2|mER|LyGPR|LERGU2|GPER1|G-protein coupled receptor 30|Lymphocyte-derived G-protein coupled receptor|FEG-1|Membrane estrogen receptor|GPER|DRY12
- Modification:Unmodified
- Storage Buffer:Aqueous buffered solution containing 0.01 M TBS (pH 7,4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- Molecular Weight:42 kDa
- Storage Temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze–thaw cycles.
- Concentration:1 µg/µl
- Shipping Temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human GPR30
- Tested Applications:ICC
- Purification:Purified by Protein A
- Cat. No.:10305-520
- Packaging:Vial
Specifications
About this item
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.
Type: Primary
Antigen: GPR30
Clonality: Polyclonal
Clone:
Conjugation: Cy5
Public Immunogen Range: 251-375/375
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat