- Antibody Type:Primary
- Antigen Name:GPCR RDC1
- Clonality:Polyclonal
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Western Blot:Yes
- Size:100 µl
- Epitope:151-250/362
- Form:Liquid
- Gene ID:57007
- Antigen Synonyms:CXC-R7|G-protein coupled receptor 159|ACKR3|RDC-1|G-protein coupled receptor RDC1 homolog|CXCR-7|GPR159|CMKOR1|Chemokine orphan receptor 1|CXCR7_HUMAN|RDC1|C-X-C chemokine receptor type 7|CXCR7
- Modification:Unmodified
- Storage Buffer:Aqueous buffered solution containing 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
- Molecular Weight:41 kDa
- Storage Temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping Temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human GPCR RDC1
- Tested Applications:ICC
- Purification:Purified by Protein A
- Cat. No.:10315-140
- Packaging:Vial
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
Type: Primary
Antigen: GPCR RDC1
Clonality: Polyclonal
Clone:
Conjugation: FITC
Public Immunogen Range: 151-250/362
Host: Rabbit
Isotype: IgG
Reactivity: