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Specifications
- Antibody Type:Primary
- Antigen Name:Galectin-3
- Clonality:Monoclonal
- Clone:H-5
- Conjugation:Unconjugated
- Host:Mouse
- Isotype:IgG2a kappa
- Reactivity:Human
- Size:6 ml
- Cat. No.:76634-516
Specifications
About this item
Galectin-3 is a member of the beta-galactoside-binding protein family that plays an important role in cell adhesion, cell matrix interactions, macrophage activation, angiogenesis, metastasis, and apoptosis.
Galectin-3 shows strong diffuse cytoplasmic staining in most cases of papillary thyroid carcinoma (PTC), most poorly differentiated thyroid cancers demonstrate galectin-3 protein expression while it is not expressed in anaplastic thyroid cancers. (1) Upregulated expression of galectin-3 is involved in cancer progression and metastasis, and it is suggested that Galectin-3 may be a valuable tool to support diagnosis of parathyroid carcinoma. (2)
Galectin-3 has also been reported to play important roles in the progression of prostate cancer, and their heterogeneous expressions might be associated with different cancer subtypes. (3)