Sub-2 µm UHPLC size exclusion columns for maximum resolution in protein aggregation analysis and SEC-MS.

• High resolution, high-efficiency separation, and accurate quantitation for aggregates and fragments analysis
• Reduced secondary interactions with mAb, ADC, and other proteins
• Assured consistent column performance to eliminate rework
• Enhanced column lifetime and productivity to meet robust CQA analysis

The AdvanceBio SEC 1.9 µm columns are designed to improve resolution and provided faster separation of protein aggregates and fragments by UHPLC. The optimized sub-two-micron particles are monodispersed and modified by unique hydrophilic bonding chemistry providing column reproducibility, stability as well as preventing secondary interactions and protein adsorption. The AdvanceBio SEC 1.9 μm column is intended to meet the needs for qualitative and quantitative critical quality attributes (CQA) analysis and method transferability across departments.