CD40-Ligand, or CD154, is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40-Ligand binds and activates the CD40 receptor on antigen-presenting cells. CD40-Ligand stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion. CD40-Ligand also induces cytokine production and tumoricidal activity in peripheral blood monocytes. CD40-Ligand is a co-stimulator of activated T cell proliferation and inflammatory protein production.
- High Quality
- Low Endotoxin
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A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions. This product is for research use only and is not for use in humans.
- Conjugation:Unconjugated
- Protein Function:Cytokine
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:–20 °C
- Endotoxin Content:Endotoxin LAL (EU/µg) ≤0.1
- Biological Activity:Bioactivity assay: Activity of HEK-blue™ CD40L cells, ED50 ≤50 ng/ml, Bioactivity ≥2.0×10⁴ units/mg
- Gene ID:P29965
- Reconstitution Instructions:Sterile water at 0.1 mg/ml
- Endotoxin-free:N
- Carrier-Free:Y
- Protease-free:N
- Animal-Free:Y
- Protein Synonyms:TRAP|gp39|CD154|T-BAM|TNFSF5
- Protein/Peptide Name:CD40-Ligand
- Purity:≥95%
- Molecular Weight:16.3 kDa
- Sequence:MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
- Endotoxin Level:Low
- Formulation:10 mM sodium phosphate, pH 7.5
- Nuclease-free:N
- Grade:RUO
- Shipping Temperature:RT
- Tested Applications:Bioassay