Human;Mouse;Rat Recombinant GDF-11 (from E. coli)
Catalog # 76303-724
Supplier: Peprotech
CAS Number:
Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:HumanRatMouse
- Size:50 µg
- Biological Activity:Assay #1: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 ug/ml. Assay #2: Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1cells. The ED50 for this effect is 8-10 ng/ml.
- Gene ID:10220
- Animal-Free:Y
- Protein Synonyms:BMP-11|Growth/Differentiation Factor-11
- Protein/Peptide Name:GDF-11
- Purity:98%
- Molecular Weight:25 kDa
- Sequence:NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
- Endotoxin Level:Low
- Formulation:Lyophilized
- Shipping Temperature:Ambient
- Cat. No.:76303-724
Specifications
About this item
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves the arrest of the progenitor cell cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggest that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant Human/Murine/Rat GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8, sharing 90% amino acid sequence identity.