Human Recombinant IL-34 (from HEK293 Cells)
Catalog # 76303-798
Supplier: Peprotech
CAS Number:
Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:50 µg
- Biological Activity:Measured by its ability to induce secretion of MCP-1 from PBMCs.
- Gene ID:146433
- Animal-Free:Y
- Protein Synonyms:C16orf77|Interleukin-34
- Protein/Peptide Name:IL-34
- Purity:95%
- Molecular Weight:52.5 kDa
- Sequence:NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH
- Endotoxin Level:Low
- Formulation:Lyophilized
- Shipping Temperature:Ambient
- Cat. No.:76303-798
Specifications
About this item
IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.