MabSelect™ PrismA Protein A Chromatography Resin, Cytiva

MabSelect™ PrismA has been improved with an optimised high-flow agarose base matrix and a genetically engineered protein A-derived ligand, allowing future demands in mAb processing to be met.

Enhanced dynamic binding capacity allows high mass throughput of processed mAb per resin volume unit
Excellent alkaline stability enables efficient cleaning and sanitisation using 0.5 to1.0 M NaOH for improved process economy, bioburden, control and robustness
Covered by a comprehensive security of supply program, including dual sources of the agarose base matrix and protein A ligand

MabSelect™ PrismA builds on the proven track record of MabSelect™ and MabSelect™ SuRe™ resins in commercial mAb production.

pH Range:
3 – 12
Matrix:
Rigid, highly cross-linked agarose
Ligand:
Alkaline-stabilised protein A-derived (E.coli)
Storage Temperature:
2 - 8 °C
Binding Capacity:
~ 40 mg polyclonal IgG/ml resin, 2 min residence time
~ 80 mg polyclonal IgG/ml resin, 6 min residence time
Ligand Coupling Method:
Epoxy