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Anti-THEM4 Rabbit Polyclonal Antibody
Anti-THEM4 Rabbit Polyclonal Antibody
  75932-864
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Anti-THEM4 Rabbit Polyclonal Antibody
  75932-864
 :  600-401-FE0

 

  • Antibody Type:
    Primary
  • Antigen Symbol:
    THEM4
  • Clonality:
    Polyclonal
  • ELISA:
    Yes
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Western Blot:
    Yes
  • Size:
    100 µg
  • Storage Temperature:
    Store vial at –20 °C. Aliquot contents and freeze at –20 °C. Centrifuge product if not completely clear after standing at room temperature. Stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use.
  • Shipping Temperature:
    Dry Ice
  • Purification:
    Affinity purified
  • Cat. No.:
    75932-864
  • Supplier no.:
    600-401-FE0

 

 

THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.

Anti-THEM4 Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 27 kDa in Western Blots of specific cell lysates and tissues.

Type: Primary
Antigen: THEM4
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: