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Specifications
- Antibody Type:Primary
- Antigen Symbol:STAT2
- Clonality:Polyclonal
- ELISA:Yes
- Host:Rabbit
- Isotype:
- Reactivity:
- Western Blot:Yes
- Size:25 µL
- Environmentally Preferable:
- Shipping Temperature:Dry Ice
- Purification:Affinity purified
- Cat. No.:75932-190
- Supplier no.:600-401-H38S
Specifications
About this item
STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. STAT2pS734 antibody is ideal for researchers focused in cancer and transcripton factor research.
Anti-STAT2 pS734 antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 97.9 kDa in size corresponding to STAT2pS734 protein by western blotting in the appropriate cell lysate or extract.
Type: Primary
Antigen: STAT2
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: