Anti-EIF2AK2 Rabbit Polyclonal Antibody
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Product Details & Documents
The interferon-inducible, double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family, possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system. Upon binding dsRNA, PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2, resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
Anti-PKR Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 62 kDa in Western Blots of specific cell lysates and tissues.
Type: Primary
Antigen: EIF2AK2
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity:
Documents
Specifications
- Size:100 µg
- Cat. No.:75931-040
- Clonality:Polyclonal
- Western Blot:Yes
- Purification:Affinity purified
- Shipping Temperature:Dry Ice
- Antibody Type:Primary
- Antigen Symbol:EIF2AK2
- ImmunoFluorescence:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ELISA:Yes
- Storage Temperature:Store vial at –20 °C. Aliquot contents and freeze at –20 °C. Centrifuge product if not completely clear after standing at room temperature. Stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use.
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