- Antibody Type:Primary
- Antigen Symbol:DDIT4
- Clonality:Polyclonal
- ELISA:Yes
- Host:Rabbit
- Western Blot:Yes
- Size:100 µL
- Modification:Phosphorylation
- Storage Temperature:Store vial at –20 °C prior to opening in undiluted aliquots. Aliquot contents and freeze at –20 °C. Centrifuge product if not completely clear after standing at room temperature. Dilut
- Shipping Temperature:Wet Ice
- Purification:Affinity purified
- Cat. No.:75931-496
- Supplier no.:600-401-X24
REDD1, Regulated in Development and DNA damage responses 1, is induced by hypoxia, cell stress, and apoptosis. Reduced REDD1 levels can sensitize cells towards apoptosis, where elevated levels of REDD1 induced by hypoxia can desensitize cells to apoptotic stimuli. REDD1 has a crucial role in inhibiting mammalian rapamycin complex 1 (mTORC1) signaling during hypoxic stress. It has been shown that the rapid degradation of REDD1 is mediated by the CUL4A–DDB1–ROC1–b-TRCP E3 ligase complex and is regulated by REDD1 phosphorylation at Thr 25, Thr 23 and Ser 19 through the activity of GSK3b. REDD1 pT23/25 Antibody is ideal for researchers interested in cancer research.
Anti-Phospho-Thr23/25 REDD1 Antibody is stored with 100 μg per ml BSA. It is suitable for Western Blots and is specific for the ~34 kDa REDD1 phosphorylated at Thr23/25. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Specific conditions for reactivity should be optimized by the end user.
Type: Primary
Antigen: DDIT4
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: