Recombinant Rat IL-1 beta control protein

• Control Protein
• PCA Assays
• ImmunoBlot

Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine, produced in response to inflammatory agents by a variety of cells, including, monocytes, macrophages, and dendritic cells (DCs). IL-1β and IL-1α are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1α is cell associated and IL-1β is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors. Recombinant rat IL-1β is a non-glycosylated protein, containing 152 amino acids, with a molecular weight of 17.3 kDa.

Interleukin-1-beta Recombinant Protein is suitable as a control for polyclonal or monoclonal anti-Interleukin-1-beta in immunological assays.