TET1 control protein-GST fusion

• Control Protein
• PCA Assays
• ImmunoBlot

TET1 Protein or tet methylcytosine dioxygenase 1 is the original member of a family of methylcytosine dioxygenases that perform several steps required for cytosine demethylation and gene activation (1). TET proteins have potential roles in epigenetic regulation through modification of 5mC to hmC. TET1 plays a main role in modulating DNA methylation levels at CpG-rich promoters and also helps in promoting transcription of pluripotency factors as well as participating in the repression of Polycomb-targeted developmental regulators (2). TET1 Protein is ideal for investigators involved in Signaling Proteins, Methylcytosine Dioxygenase Proteins, Cancer, and Cell Cycle research.

TET1 Protein is stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. TET1 Protein is suitable for use in Western Blot. Expect a band approximately ~110kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.