About this item
Catenin α is a novel actin-binding and -bundling protein. Catenin α is responsible for organizing and tethering actin filaments at the zones of E-cadherin-mediated cell-cell contact (1). Monomeric Catenin α can bind strongly to E-Cadherin-β-Catenin, whereas the dimer preferentially binds actin filaments. Different molecular conformations are associated with these different binding states, indicating that Catenin α is an allosteric protein. Catenin α directly regulates actin-filament organization by suppressing Arp2/3-mediated actin polymerization, likely by competing with the Arp2/3 complex for binding to actin filaments (2). Catenin α Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, Cancer, Cardiovascular Disease, Invasion/Metastasis, Neurobiology, PKA/PKC Pathway, and WNT Signaling research.
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Specifications
- Protein/Peptide Type:Recombinant
- Source:Baculovirus (Sf9 Insect cells)
- Species:Human
- Storage Conditions:Store product at –70 °C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- Protein Synonyms:CAP102|FLJ36832|Catenin alpha-1|CTNNA1|Cadherin-associated protein|Renal carcinoma antigen NY-REN-13|Alpha E-catenin
- Protein/Peptide Name:CTNNA1
- Purity:>95%
- Formulation:Liquid (sterile filtered)
- Shipping Temperature:Dry Ice