Human Recombinant EIF4EBP1 (from Insect cells (Sf9))

4EBP1 is a member of a family of translation repressor proteins that directly interact with eukaryotic translation initiation factor 4E (EIF4E). Interaction of 4EBP1 with EIF4E inhibits the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs thereby leading to repression of translation. Insulin treatment of adipose cells increases the phosphorylation of 4EBP1 and leads to reduced interaction of 4EBP1 with EIF4E (1). 4EBP1 is expressed in most tissues, with highest levels seen in adipose tissue, pancreas, and skeletal muscle (2). 4EBP1 Protein is ideal for investigators involved in Signaling Reagents, Protein Substrates, AKT/PKB Pathway, Angiogenesis, Cancer, and Metabolic Disorder research.

Protein/Peptide Type:
Recombinant
Source:
Insect cells (Sf9)
Species:
Human
Storage Conditions:
Store product at –70 °C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Protein Synonyms:
Phosphorylated heat- and acid-stable protein regulated by insulin 1|PHAS-I|EIF4EBP1|BP-1|MGC4316|eIF4E-binding protein 1|Eukaryotic translation initiation factor 4E-binding protein 1|4E-BP1
Protein/Peptide Name:
EIF4EBP1
Purity:
>85%
Formulation:
Liquid (sterile filtered)
Shipping Temperature:
Dry Ice