Human Recombinant BMP-4 (from CHO cells)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

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Supplier: FUJIFILM IRVINE SCIENTIFIC, INC

About this item

Myostatin, also known as GDF-8, is a conserved member of the TGF-beta superfamily. Myostatin is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size.

High quality
Low endotoxin
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Myostatin binds one of the two activin type II receptors (ACTRIIA or ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.

Caution: For research use only.

Specifications

Conjugation:
Unconjugated
Protein Function:
Cytokine
Protein/Peptide Type:
Recombinant
Source:
CHO cells
Species:
Human
Storage Conditions:
−20 °C
Endotoxin Content:
Endotoxin LAL (EU/µg) ≤0.1
Biological Activity:
Bioactivity assay: Alkaline phosphatase activity induced in ATDC-5 cells, ED50 ≤15 ng/ml, bioactivity ≥6.7×10⁴ units/mg
Gene ID:
P12644
Reconstitution Instructions:
Sterile 10 mM HCl at 0.1 mg/ml
Endotoxin-free:
N
Carrier-Free:
Y
Protease-free:
N
Animal-Free:
N
Protein Synonyms:
BMP-2B
Protein/Peptide Name:
BMP-4
Purity:
≥95%
Molecular Weight:
13.1/26.2 kDa
Sequence:
SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
Endotoxin Level:
Low
Formulation:
0.1% Trifluoroacetic Acid (TFA)
Nuclease-free:
N
Grade:
RUO
Shipping Temperature:
RT
Tested Applications:
Bioassay