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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:10 μg
- Environmentally Preferable:
- Storage Conditions:–20 °C
- Endotoxin Content:< 1.0 EU per/μg
- Gene ID:P20138
- Reconstitution Instructions:Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
- Protein Synonyms:gp67|SIGLEC3|CD33
- Protein/Peptide Name:CD33
- Molecular Weight:52.9 kDa
- Formulation:Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
- Shipping Temperature:Gel Pack
- Cat. No.:76289-236
Specifications
About this item
Myeloid cell surface antigen CD33 also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 Domain (s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.