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Specifications
- Description:Zonisamide HPLC Assay
- Size:1 kit
- Cat. No.:102995-118
- Supplier no.:ZON31-H100
Specifications
About this item
The Zonisamide HPLC Assay detects Zonisamide in serum and plasma.
- Incubation Time: 15 minutes
- Sample Size: 100 µl
- Sample Type: Serum, Plasma
The antiepileptic drug Zonisamide is used as add on therapy for the treatment of epileptic disorders. Zonisamide, a benzisoxazol-derivative, doesn´t show any similarities to other antiepileptic drugs on the market. The therapeutic range of the serum concentration of this drug during dosing is rather narrow; high doses often cause side effects such as ataxia, nystagumus, diplopia, drowsiness, loss of appetite and more. Clinically significant effects are observed with plasma levels higher than 16.5 mg/l, and some toxic symptoms may occur when the plasma concentration exceeds 40 mg/l (Sackellares et al, 1985). Therefore the determination of the plasma concentration is required in epileptic patients, in order to establish a proper concentration of the drug for the inhibition of epileptic seizures and to avoid side effects during chronic drug administration.