About this item
This antibody recognizes a protein of 12 kDa, identified as β2-microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of analpha heavy chain that contains three subdomains (α1,alpha2,alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with thealpha3 subdomain of thealpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. Thealpha1 andalpha2 domains of thealpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
Type: Primary
Antigen: B2M
Clonality: Monoclonal
Clone: Clone B2M/961
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human, Non-human primates
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Specifications
- Catalog No:
- 75882-080
- 75882-082
- Antigen Symbol:
- B2M
- B2M
- Antigen Name:
- Beta-2 Microglobulin
- Beta-2 Microglobulin
- Antibody Type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Unconjugated
- Unconjugated
- Clone:
- B2M/961
- B2M/961
- Reactivity:
- Non-human primates, Human
- Non-human primates, Human
- Host:
- Mouse
- Mouse
- Gene ID:
- Unigene ID: 534255
- Unigene ID: 534255
- Isotype:
- IgG2b kappa
- IgG2b kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0.2 mg/mL
- 0.2 mg/mL
- Storage Buffer:
- PBS/0.05% BSA/0.05% azide
- PBS/0.05% BSA/0.05% azide