About this item
This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.
Type: Primary
Antigen: TP53
Clonality: Monoclonal
Clone: Clone TRP/817
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human
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Specifications
- Catalog No:
- 75969-170
- 75967-720
- Antigen Symbol:
- TP53
- TP53
- Antigen Name:
- p53
- p53
- Antibody Type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 640R
- CF® 640R
- Clone:
- TRP/817
- TRP/817
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- Unigene ID: 654481
- Unigene ID: 654481
- Isotype:
- IgG2b kappa
- IgG2b kappa
- Western Blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0.1 mg/mL
- 0.1 mg/mL
- Storage Buffer:
- PBS/0.1% BSA/0.05% azide
- PBS/0.1% BSA/0.05% azide