Sensitive Human Fetuin-A ELISA detects human Fetuin-A, in serum.

• Dynamic Range: 0 -4343 ng/mL
• Sensitivity: 40 ng/mL
• Incubation: 3 hours

Fetuin-A, also known as alpha-2-HS glycoprotein, is a 59 kDa glycoprotein that consists of two amino-terminal cystatin domains and a smaller carboxyl-terminal domain. Fetuin-A is synthesized by the liver and secreted into blood stream, where its concentration in adult mammals ranges from 0.5 – 1.5 g/L. Fetuin-A occurs in high serum concentration during fetal life and involves in protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. It accumulates in bones and teeth as a major fraction of noncollagenous bone proteins. Biologically, studies have demonstrated that Fetuin-A is the major calcification inhibitor found in serum, where it interferes with calcium salt precipitation. A recent study has indicated that Fetuin-A level drops in uremic patients on hemodialysis in comparison to normal healthy controls. The low Fetuin-A level may be associated with a higher cardiovascular mortality in patients on dialysis.