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- Host:
- Primary antibody reactivity:
- Target protein:ALS
- Description:ALS (Acid Labile Subunit) ELISA
- Size:1 kit
- Environmentally Preferable:
- Cat. No.:102994-312
- Supplier no.:E35
ALS ELISA is suited for the measuring ALS in human serum or EDTA-/heparin-/citrate plasma.
- Dynamic Range: 1.5 - 40 mU/ml
- Sensitivity: 0.2 mU/ml
- Incubation: 3 hours
The acid-labile Subunit, is a synthezised as propeptide of 605 amino acids. The signal peptide, necessary for ALS secretion (AA 1-27) cleaved off enduring the transport process (Swiss-Prot P35858 Version 82). The mature protein consists of 578 amino acids and contains about 20 leucin rich sequence repeats. Beside the leucin-rich repeats several potential N-linked glycosylation sides have been described. Miller BS et al. were able to demonstrate that incomplete glycolsylation of IGFs, ALS and IGFBP-3 results in a decreased serum concentration of these proteins. Oral mannose therapy resulted in a partial normalization of the glycosylation pattern and went along with improved growth [8]. Mutations in or the complete knock out of the ALS gene result in IGF / IGFBP-3 deficiency and therewith in disturbation of growth [9,10]. Beside growth also other Endocrinology axes may be involved. In primary ALS deficiency hyperinsulinemia could be observed [11, 12]. Further, the ALS-IGF-IGFBP-system seems to be of relevance in coronary disease [13].