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Specifications
- Host:
- Primary antibody reactivity:
- Description:hGH Sensitive ELISA
- Size:1 kit
- Environmentally Preferable:
- Cat. No.:102994-264
- Supplier no.:E022
Specifications
About this item
hGH Sensitive ELISA is quantitatively measures levels of human growth hormone in serum and plasma.
- Dynamic Range: 0.05 - 1.0 ng/mL
- Sensitivity: 12 pg/ml
- Incubation: 2.5 hours
The Endocrinology system of human Growth Hormone (hGH), also named Somatropin, is characterized by an extreme complexity. hGH is the product of the GH-1 gene located on chromosome 17 and expressed in pituitary cells. 80% of the gene expression results in a non-glycolsylated 22 kDa protein consisting of 191 amino acids. The other 20% of gene expression results in a variant form of 20 kDa by alternative splicing. Additionally, several smaller variants can be found in circulation as well as translational modified proteins and different degrees of protein aggregation. Further on, bioactivity of Growth Hormone is regulated by a specific binding protein (GHBP) formed by the extra cellular part of the cellular transmembran GH-receptor. These modifications allow a tight control of the half-life period hGH and of its bioactivity.