Specifications
- Antibody Type:Primary
- Antigen Name:thyroid stimulating hormone receptor
- Antigen Symbol:TSHR
- Clonality:Monoclonal
- Clone:SPM222
- Conjugation:Unconjugated
- Flow Cytometry:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG2a
- Reactivity:Human
- Size:100 ug
- Format:Purified Antibody
- Form:Liquid
- Gene ID:P16473
- Antigen Synonyms:TSHR
- Storage Buffer:PBS with 0.1 mg/ml BSA and 0.05% sodium azide
- Storage Temperature:Aliquot and Store at 2…8 °C. Avoid freez-thaw cycles.
- Concentration:0.2 mg/mL
- Shipping Temperature:4 °C
- Immunogen:Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.
- Purification:Protein G affinity chromatography
- Cat. No.:76194-708
Specifications
About this item
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Flow Cytometry: 0.5-1ug/10^6 cells in 0.1ml IF: 1-2 ug/ml IHC (FFPE): 1-2 ug/ml for 30 min at RT The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TSH Receptor antibody to be titered up or down for optimal performance.
Type: Primary
Antigen: TSHR
Clonality: Monoclonal
Clone: SPM222
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human