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- Antibody Type:Primary
- Antigen Name:Integrin subunit alpha 4
- Antigen Symbol:ITGA4
- Clonality:Monoclonal
- Clone:DATK32
- Conjugation:APC (Allophycocyanin)
- Flow Cytometry:Yes
- Host:Rat
- Isotype:IgG2a kappa
- Reactivity:Mouse
- Size:100 μg
- Environmentally Preferable:
- Form:liquid
- Antigen Synonyms:LPAM-1|ITGA4|CD49d/β7|ITGB7
- Cat. No.:75842-586
- Supplier no.:83212-80-100
The DATK32 monoclonal antibody specifically reacts with an epitoPEof the Mouseα4β7 integrin (LPAM-1). The two subunits of the LPAM-1 heterodimer are the 154 kDa α4 and the 130 kDa β7. Most mature lymphocytes, a subset of bone marrow cells, and some of the thymic cells express the α4β7 integrin heterodimer. α4β7 enhances the transendothelial migration of lymphocytes, and interacts with several ligands (fibronectin, CD106, and MAdCAM-1). The interaction of DATK32 with the α4β7 induces the α4β7-dependent lymphocyte aggregation and inhibits LPAM-1-dediated cell adhesion.
Type: Primary
Antigen: ITGA4
Clonality: Monoclonal
Clone: DATK32
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Rat
Isotype: IgG2a, kappa
Reactivity: Mouse