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Specifications
- Conjugation:Unconjugated
- Source:E. coli
- Species:Human
- Size:100 µl
- Storage Conditions:–78 °C
- Protein Synonyms:MMP-8 Proenzyme|Matrix metalloproteinase 8|MMP-8 recombinant
- UniProtKB:P22894
- Protein/Peptide Name:MMP-8
- Molecular Weight:85 kDa
- Concentration:10 μg/mL
- Cat. No.:103010-284
- Supplier no.:AS-72008
Specifications
About this item
Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-8 (neutrophil collagenase) is synthesized by neutrophils and stored in the specific granules until it is secreted.
Human MMP-8 is a full length pro-enzyme isolated from stimulated human neutrophil granulocytes. Proenzyme can be activated by incubating with 1 mM APMA at 37°C for 1 hr. Its activity can be measured in FRET-based enzymatic assays. 10-20 ng of enzyme is sufficient for FRET-based assay.