About this item
Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys
The sequence (Accession # CAQ10087) corresponding to the extracellular domain of human MOG along with a 6x His tag was expressed in E. coli. The recombinant human MOG (H-rMOG) was purified from urea denatured bacterial lysate using immobilized metal affinity chromatography (IMAC). The molecular mass of the recombinant human MOG is 14.2 kDa
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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:–78 °C
- Endotoxin Content:Less than 0.1 EU per 1 μg of the protein as determined by Limulus Amebocyte Lysate (LAL) quantitative kinetic assay.
- Protein Synonyms:myelin oligodendrocyte protein recombinant|MOG 1-125 recombinant
- UniProtKB:Q16653
- Protein/Peptide Name:MOG (1-125)
- Purity:>95% as estimated by SDS-PAGE
- Molecular Weight:14.2 kDa