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- Conjugation:Unconjugated
- Size:1 mg
- Storage Conditions:–20 °C
- Protein Synonyms:Prion protein fragment 106-126
- Protein/Peptide Name:PrP (106-126)
- Purity:95%
- Molecular Weight:1912.3 Da
- Sequence:KTNMKHMAGAAAAGAVVGGLG
- Cat. No.:103006-372
- Supplier no.:AS-61160
Prion protein (PrP), also known as CD230, is mainly produced in the nervous sytem. PrP exists as different isoforms, among which the normal PrPc, and the 'scrapie' isoform PrPSc. PrPSc is misfolded and associated to multiple disorders including bovine spongiform encephalopathy, Gerstmann-Straüssler-Scheindker disease (GSS) and the Creutzfeldt-Jakob disease. It contains a much higher beta-sheet content than PrPc, and tends to form protease-resistant aggregates. A hypothesis to support the propoagation of these aggregates and their role in neurodegeneration is that the change from normal PrPc is due to its interaction with PrPSc 'conformation conversion hypothesis).
PrP 127-147 forms filamentous structures ressembling scrapie-associated fibrils, but possesses a lower amyloidogenic potential than PrP 106-126.
Sequence:KTNMKHMAGAAAAGAVVGGLG
MW:1912.3 Da
% peak area by HPLC:95
Storage condition:-20° C