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Specifications
- Conjugation:DABCYL-EDANS
- Size:1 mg
- Storage Conditions:–20 °C
- Protein Synonyms:MMP FRET|MMP Substrate III|Matrix Metalloproteinase substrate III
- Protein/Peptide Name:490 MMP FRET Substrate III
- Purity:95%
- Molecular Weight:1497.8 Da
- Sequence:DABCYL-RPLALWRS-EDANS
- Cat. No.:102996-784
- Supplier no.:AS-27104
Specifications
About this item
Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide has an optimized sequence for MMP-7, with the cleavage occuring at the Ala-Leu bond. The substrate is used for high throughput screening of MMP-7 inhibitors. Abs/Em = 340/490 nm.
Sequence:DABCYL-RPLALWRS-EDANS
MW:1497.8 Da
% peak area by HPLC:95
Storage condition:-20° C