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Specifications
- Conjugation:Mca-DNP
- Size:5 mg
- Storage Conditions:–20 °C
- Protein Synonyms:MMP FRET|MMP Substrate IV|Matrix Metalloproteinase substrate IV
- Protein/Peptide Name:390 MMP FRET Substrate IV
- Purity:95%
- Molecular Weight:1100.2 Da
- Sequence:Mca-P-Cha-G-Nva-HA-Dap(Dnp)-NH2
- Cat. No.:102996-792
- Supplier no.:AS-27109
Specifications
About this item
Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This substrate is readily hydrolyzed by MMP-8, 9 and collagenase-3 (MMP-13), Abs/Em = 325/393 nm. The hydrolysis is inhibited in a 1:1 stoichiometric fashion by the tissue inhibitors of metalloproteinases, TIMP-1, TIMP-2, and TIMP-3.
Sequence:Mca-P-Cha-G-Nva-HA-Dap(Dnp)-NH2
MW:1100.2 Da
% peak area by HPLC:95
Storage condition:-20° C