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- Conjugation:Unconjugated
- Species:HIV
- Size:1 mg
- Storage Conditions:–20 °C
- Protein Synonyms:Fusion TAT HA2|TAT fusion|HA2 TAT
- Protein/Peptide Name:TAT-HA2 Fusion Peptide
- Purity:95%
- Molecular Weight:3433 Da
- Sequence:RRRQRRKKRGGDIMGEWGNEIFGAIAGFLG
- Cat. No.:103008-568
- Supplier no.:AS-64876
This sequence is amino acids 1 to 20 of influenza A virus hemagglutinin protein (HA2) connected to a 10 amino acid cell permeable HIV Trans-Activator of Transcription (TAT) protein transduction domain (PTD). TAT-HA2 is capable of being used as a large macromolecule drug delivery peptide. The TAT PTD binds to the cell surface and penetrates the membrane via lipid raft-dependent macropinocytosis. Endosomal escape and transduction of the fusion peptide are enhanced by the HA2 domain, which is a pH-sensitive lipid membrane destabilizing sequence.
Sequence: RRRQRRKKRGGDIMGEWGNEIFGAIAGFLG
MW: 3433 Da
% Peak area by HPLC: 95
Storage condition: -20°C