About this item
Full-length Recombinant human alpha-synuclein (GenBank Accession # NP_000336) was expressed in E. coli., and purified from bacterial lysate using proprietary method. Endotoxin was further removed by proprietary technique.
α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.
The human α-synuclein recombinant proteins from AnaSpec are offered with low endotoxin levels of <0.1 EU per μg protein labeled as EndoClear™ products.
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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:Store at 2-4 °C for immediate use within 1-2 weeks or at –80 °C for up to 12 months.
- Endotoxin Content:<0.1EU/µg protein
- Gene ID:NP_000336
- Protein/Peptide Name:alpha-Synuclein
- Purity:> 95% as determined by SDS-PAGE
- Molecular Weight:14.5 kDa
- Endotoxin Level:Low
- Protein Synonyms:Synuclein Protein|SNCA|low endotoxin synuclein|alpha-Synuclein|low endotoxin alpha-Synuclein|Human alpha - Synuclein|alpha - Synuclein