Mouse Recombinant IL-10 (from E. coli)

Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ƴ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells. Mouse IL-10 is not active on human cells.

High quality
Low endotoxin
Affordable

: For research use only.

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Conjugation:
Unconjugated
Protein Function:
Cytokine
Protein/Peptide Type:
Recombinant
Source:
E. coli
Species:
Mouse
Storage Conditions:
–20 °C
Endotoxin Content:
Endotoxin LAL (EU/µg) ≤1
Biological Activity:
Bioactivity Assay: MC/9 cell proliferation, ED₅₀ ≤5 ng/ml, Bioactivity ≥2.0×10⁵ units/mg
Gene ID:
P18893
Reconstitution Instructions:
Sterile water at 0.1 mg/ml (reconstitution at concentrations > 0.1 mg/ml may result in a precipitate)
Endotoxin-free:
N
Carrier-Free:
Y
Protease-free:
N
Animal-Free:
N
Protein Synonyms:
Cytokine synthesis inhibitory factor|CSIF
Protein/Peptide Name:
IL-10
Purity:
≥95%
Molecular Weight:
18.9 kDa
Sequence:
MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGEKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLQDQGVYKA MNEFDIFINC IEAYMMIKMK S
Endotoxin Level:
Low
Formulation:
10 mM Sodium phosphate, pH 7.5
Nuclease-free:
N
Grade:
RUO
Shipping Temperature:
RT
Tested Applications:
Bioassay