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- Conjugation:Unconjugated
- Source:E. coli
- Size:50 µg
- Storage Conditions:–80 °C
- Form:Liquid
- Shipping Conditions:–80 °C, dry ice
- Enzyme Name:NAD Synthetase
- Enzyme Activity:~0.3 U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1µmol NAD per min.
- Purity:98%
- Molecular Weight:~30.4 kDa
- Concentration:0.5 mg/ml (Lot specific)
- Formulation:In 50 mM TRIS-HCl, pH 8, containing 75 mM sodium chloride, 5% glycerol and 5 mM DTT.
- Cat. No.:102980-454
- Supplier no.:AG40T0109C050
NAD synthetase is an essential enzyme involved in both the de novo biosynthesis and salvage of NAD+, catalyzing the final step of both pathways
- UniProt link P08164: NAD Synthetase (B. subtilis)
Since NAD has a vital role in cell metabolism, the enzyme represents a valid target for the development of new antimycobacterial agents. It was shown to be induced by heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation and is involved in biological processes like stress response and sporulation resulting in formation of a cellular spore. Catalytic activity: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+